A new modelling study published in BMC Infectious Diseases found that countries for which the spread of antimicrobial resistance is likely to lead to outbreaks of typhoid fever should consider introducing typhoid conjugate vaccines. Researchers developed a stochastic model of typhoid transmission fitted to data from Queen Elizabeth Central Hospital in Blantyre, Malawi from January 1996 to February 2015 and estimated the number of disability-adjusted life-years which could be prevented using various vaccination strategies. Reactive vaccination was also found to be a cost-effective strategy, but only if delays in vaccine deployment are minimal; otherwise, introduction of preventive routine immunization with a catch-up campaign is the preferred strategy.
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