Gavi RFP: Vaccine Portfolio Optimisation and Prioritisation (VPOP) approach

• Intent to participate due: 1 September 2025
• Closing date: 19 September 2025

As Gavi enters its “6.0” strategic period, its funding model is evolving to better empower countries, drive programmatic efficiency, and support the sustainability of immunisation systems in a resource-constrained environment. Central to this shift is the introduction of consolidated country-level envelopes—covering both programmatic (cash) support and newly approved vaccine envelopes, which define country-specific ceilings for vaccine procurement.

This model gives countries more flexibility and discretion over how they allocate Gavi resources—but also requires them to make increasingly complex, evidence-informed trade-offs within finite budget ceilings and tools. To enable this, the Alliance is developing a Vaccine Portfolio Optimisation and Prioritisation (VPOP) approach that will serve as a critical enabling function—not only for vaccine envelopes, but also for the broader implementation of Gavi’s consolidated cash grants and health systems programming that is aligned with a country’s National Immunisation Strategy (NIS).

The scope of work for this request for proposals is as following:

• Building on existing work, resources, and guidance, define a stepwise process for embedding VPOP within NIS and Gavi holistic grant application, positioning VPOP as an enabling function for Vaccine Envelope implementation.
• Design and develop a global decision framework that integrates market health data with insights from country VPOP exercises to guide the determination of optimal product mix.
  • Define the appropriate data inputs and sources (e.g., forecasting, market dynamics, country product choice data) and establish an SOP for systematic collection and synthesis.
  • Specify the essential data elements and indicate how existing tools and dashboards can be adapted or scaled for broader use.
  • Recommend priority areas for additional tool development or refinement in Gavi 6.0, with particular focus on helping countries balance prioritization and optimization against programmatic feasibility, implementation capacity, and long-term sustainability in a Vaccine Envelope context.