Economic evaluation of 22 HPV vaccination strategies to minimize the risk of penile, anal, and oropharyngeal cancers in Chinese males: A Markov model analysis

This peer-reviewed article published in Human Vaccines & Immunotherapeutics evaluates the lifetime health and economic impact of different HPV vaccination strategies for males in China. Using a decision-Markov model, the study compares 22 vaccination strategies targeting males aged 14 and 40 years against no vaccination, from a healthcare system perspective. 

Key findings 

• HPV vaccination for males was found to be highly cost-effective across most evaluated strategies (20 out of 22) under a willingness-to-pay threshold of three times GDP per capita
• Vaccinating 14-year-old males could avert 73,724 to 416,654 cancer cases and 1,102 to 6,229 deaths, depending on vaccine type and coverage
• Vaccination strategies targeting 40-year-old males also showed substantial health benefits
• Results were robust across sensitivity analyses, indicating stability across key assumptions
• The study highlights significant potential to reduce penile, anal, and oropharyngeal cancers associated with HPV in men

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