Guidance, tools & data

Applied Health Economics in Vaccines Handbook

This handbook covers principles of vaccine economics, costing immunization services, economic evaluation of vaccines and vaccine programs, and financing and resource tracking of vaccination programs [2023].

Guide to standardizing the economic evaluation of immunization programs

This guide brings together recommendations and guidance from many guidelines, tools and other documents on specific aspects of immunization and on specific vaccines [WHO, 2019].

Reference Case Guidelines for Benefit-Cost Analysis in Global Health and Development

These guidelines discuss the theory and practice of benefit-cost analysis, providing detailed information on diverse topics such as structuring the analysis, converting values across countries and over time, valuing changes in the risk of illness and death, addressing uncertainty, and reporting the results [Harvard T.H. Chan School of Public Health, 2019].

Methodological framework for estimating the value of combination vaccines

Economic evaluation of combination vaccines: checklist to conduct more comprehensive evaluations 

Economic evaluation of combination vaccines: a checklist for assessing their benefits and challenges

Return on investment methodology report

The Decade of Vaccine Economics (DOVE) project at IVAC-JHSPH published a methodology report, developed collaboratively with DOVE-ROI Core Advisory Group members from 9 institutions to support Gavi’s mid-term review and investment case. [DOVE, 2019].

Full Value of Vaccines Assessments (FVVA) framework

The Full Value of Vaccines Assessments (FVVA) framework is designed to facilitate alignment across key stakeholders and to enhance decision-making around investment in vaccine development, policy-making, procurement, and introduction, particularly for vaccines intended for use in low- and middle-income countries [WHO, 2023].

Vaccine impact and cost-effectiveness tool

The UNIVAC tool is a single universal vaccine impact and cost-effectiveness decision support model. Input estimates of age-specific disease burden, age/dose-specific vaccine coverage, and effectiveness allow for a simple evaluation of direct vaccination impact on health outcomes [ProVac Initiative, 2023].

Distributional cost-effectiveness analysis handbook

Methods for quantifying the equity impacts of health programs in high, middle, and low-income countries. The methods can be tailored to analyze different equity concerns in different decision-making contexts [University of York, 2020].

Sample Design Optimizer

This tool helps researchers develop cost-effective and efficient hierarchical clustered sample designs [EPIC Project and ProVac Initiative, 2019].

Meta-analysis of economic evaluations of vaccines to support decision making process

This presentation from IHEA 2023 covers a discussion of overall concept and methodological approach of meta-analysis of economic evaluations, a case study of influenza vaccination in elderly and health workers, and advancing methodology by addressing potential challenges [WHO, 2023].