Subnational geographical targeting for vaccination programs is a strategy focusing on vaccinating specific regions, provinces, or districts within a country. This is a potential approach for resource-constrained settings to implement, either through existing routine immunization programs or through targeted campaigns, to help reduce the burden of vaccine-preventable diseases. Getchell et al conduct a systematic review of the available cost-effectiveness evidence of subnational geographical targeting for vaccination and included 16 modelling studies in their analysis. They found that in areas of high disease burden, all studies demonstrated that geographic targeting of vaccination programs was cost effective, and 14 out of 16 studies found geographic targeting to be more cost effective than a non-targeted approach.
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