Cost-Effectiveness Analysis of Routine Outreach and Catch-Up Campaign Strategies for Measles, Mumps, and Rubella Vaccination in Chuuk, Federated States of Micronesia

This peer-reviewed article evaluates the cost-effectiveness of different outreach strategies to increase measles, mumps, and rubella (MMR) vaccination coverage among children aged 12 months to 6 years in Chuuk, Federated States of Micronesia. Using a cost-effectiveness model over a 5-year horizon, the study compares routine outreach (quarterly and biannual) and catch-up campaign strategies from a public health perspective. 

Key findings

• Quarterly routine outreach was the most effective strategy, achieving the highest number of protected children and protected person-months (PPMs)
• Biannual routine outreach was the least costly but also least effective strategy
• Quarterly routine outreach (vs status quo) generated approximately 7001 additional PPMs and 132 additional doses, at ~$3.65 per PPM
• Catch-up campaigns delivered higher coverage per event but were more resource-intensive than routine outreach
• More frequent outreach improves timeliness of vaccination, increasing cumulative protection over time
• Results were sensitive to assumptions on coverage achieved during outreach events and implementation costs

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